L-Homocystine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

L-Homocystine 是L-homocysteine 的一种氧化物，L-homocysteine 是一种抗血栓因子，血管舒张损害剂，促炎因子，也是研究心血管疾病发生机制的内质网应激反应的诱导剂。

Homocystine is the double-bonded form of homocysteine but it occurs only transiently before being converted to the harmless cystathionine via a vitamin B6-dependent enzyme. Increasing evidence supports a role for an elevation of homocysteine in schizophrenia. It has been demonstrated that neural tube defects are related to a genetic defect in homocysteine metabolism. Sufficient intake of folic acid is believed to reduce this risk by enhancing methylation of homocysteine and its conversion to methionine thereby compensating for this genetic defect (homocystinuria). Plasma homocysteine levels are elevated when folate levels are in the lower half of the normal range.

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A single or multiple doses of L-Homocystine administered to mice during organogenesis can aggravate the developmental disturbances caused by a single dose of VPA administered on GD 8. Whereas, VPA lowers significantly plasma FA and vitamin B12 concentrations, it has no direct impact on the homocysteine concentrations. Therefore, it is proposed that high levels of homocysteine disturb the FA, vitamin B12, and possibly methionine metabolism thus providing a favorable situation for VPA to interfere with the development of susceptible embryos.

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Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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626-72-2

268.35

C8H16N2O4S2

>98% (HPLC)

DMSO: 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 5 with HCl); H2O: 1 mg/mL (3.73 mM; ultrasonic and adjust pH to 2 with HCl)

N[C@@H](CCSSCC[C@H](N)C(O)=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years