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Estrogen receptor modulator 1
CAS No. 63676-22-2
Estrogen receptor modulator 1 ( —— )
产品货号. M24648 CAS No. 63676-22-2
雌激素受体调节剂 1 可使他莫昔芬耐药、激素非依赖性异种移植肿瘤消退。雌激素受体调节剂 1 是一种口服活性选择性雌激素受体调节剂 (SERM) (pIC50: 0.46)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥112 | 有现货 |
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| 10MG | ￥187 | 有现货 |
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| 25MG | ￥369 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥124 | 有现货 |
|
生物学信息
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产品名称Estrogen receptor modulator 1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述雌激素受体调节剂 1 可使他莫昔芬耐药、激素非依赖性异种移植肿瘤消退。雌激素受体调节剂 1 是一种口服活性选择性雌激素受体调节剂 (SERM) (pIC50: 0.46)。
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产品描述Estrogen receptor modulator 1 causes regression of Tamoxifen-resistant, hormone-independent xenograft tumors. Estrogen receptor modulator 1 is an orally active and selective estrogen receptor modulator (SERM) (pIC50: 0.46).
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体外实验Estrogen receptor modulator 1 (compound 18) (100 nM; 10 days)inhibits T47D:A18/PKCα and T47D:A18-TAM1 colony formation.Estrogen receptor modulator 1 (100 nM; 9 days) significantly inhibits the growth of MCF-7:5C cell, and induces apoptosis in these cells 6 days. Cell Proliferation Assay Cell Line:T47D:A18/PKCα and T47D:A18-TAM1 cells Concentration:100 nM Incubation Time:10 days Result:Inhibit T47D:A18/PKCα and T47D:A18-TAM1 colony formation.Cell Viability Assay Cell Line:MCF-7:5C cells Concentration:100 nM Incubation Time:9 days Result:Significantly inhibited the growth of MCF-7:5C cells.
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体内实验Estrogen receptor modulator 1 (1.5 mg/animal; p.o. ; daily for 2 weeks) results in regression of T47D:A18/PKCα tumors. Animal Model:4-6 week old athymic mice (Harlan-Sprague-Dawley) Dosage:1.5 mg/animal Administration:p.o. ; daily for 2 weeks Result:Significantly reduced tumor volume.
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同义词——
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通路Endocrinology/Hormones
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靶点Estrogen Receptor/ERR
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受体Estrogen Receptor/ERR
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研究领域——
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适应症——
化学信息
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CAS Number63676-22-2
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分子量242.29
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分子式C14H10O2S
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纯度>98% (HPLC)
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溶解度DMSO:10 mM
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SMILESOC1=CC=C(C=C(C2=CC=C(O)C=C2)S3)C3=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Brogi S, et al. 3D-QSAR using pharmacophore-based alignment and virtual screening for discovery of novel MCF-7 cell line inhibitors. Eur J Med Chem. 2013 Sep;67:344-51.
