AS-041164

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AS-041164 是一种选择性口服活性 PI3Kγ 同工型抑制剂（IC50 为 70 nM），对 PI3Kα、PI3Kβ 和 PI3Kδ 的活性较低（IC50 分别为 240 nM、1.45 μM 和 1.70 μM）。

AS-041164 is a selective and orally active PI3Kγ isoform inhibitor(IC50 of 70 nM), and shows less activity against PI3Kα, PI3Kβ, and PI3Kδ (IC50s of 240 nM, 1.45 μM, and 1.70 μM, respectively). It has anti-inflammatory effects.

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AS-041164 (10-100 mg/kg; oral administration; once) treatment results in the reduction of inflammatory swelling in the model of carrageenan-induced paw edema.AS-041164 (3-100 mg/kg p.o.) treatment dose-dependently decreases r-h regulated on activation normal T cell expressed and secreted (RANTES)-induced neutrophil recruitment in mice. The ED50 value for AS-041164 is 27.35 mg/kg. AS-041164 blocks RANTES-induced chemotaxis and reduces the level of AKT phosphorylation. Animal Model:Male Wistar rats (100-150 g) injected with carrageenan Dosage:10 mg/kg, 30 mg/kg, 100 mg/kg Administration:Oral administration; onceResult:Induced a significant reduction of paw thickness.

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PI3K/Akt/mTOR signaling

PI3K

PI3Kα|PI3Kβ|PI3Kγ|PI3Kδ

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6318-41-8

249.24

C11H7NO4S

>98% (HPLC)

DMSO:125 mg/mL (501.52 mM; Need ultrasonic)

O=C(N1)/C(SC1=O)=C/C2=CC=C3C(OCO3)=C2

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(-20℃)

With Ice Pack

≥ 2 years