SN-32976

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SN-32976 是一种新型、有效、选择性的 I 类 PI3K 和 mTOR 抑制剂。

SN-32976 is a novel, potent and selective class I PI3K and mTOR inhibitor with IC50 of 15.1/461/110/134/194 nM for PI3Kα/PI3Kβ/PI3Kγ/PI3Kδ/mTOR, respectively; displays preferential activity for PI3Kα and spares PI3Kδ relative to the other inhibitors, and shows less off-target activity in a panel of 442 kinases; inhibits pAKT expression and cell proliferation at nM concentration, induces a greater extent and duration of pAKT inhibition in tumors than pictilisib, dactolisib and omipalisib in animal models.

Western Blot Analysis Cell Line:U-87 MG cells Concentration:1 nM, 3 nM, 10 nM, 30 nM, 100 nM Incubation Time:for 1 h Result:Inhibited both Thr308 and Ser473 pAKT expression in U-87 MG cells.

Animal Model:6-8 week old female balb/c nude or female balb/c Rag1?/? mice inoculated with U-87 MG cells Dosage:37.5 mg/kg; 75 mg/kg Administration:po; daily; for 21 days Result:Inhibited tumor growth in U-87 MG tumor xenograft models.

SN 32976 | SN32976

PI3K/Akt/mTOR signaling

PI3K

PI3K

Cancer

——

1246202-11-8

581.64

C24H33F2N9O4S

>98% (HPLC)

——

CN(C)CCS(=O)(=O)N1CCN(CC1)C2=NC(=NC(=N2)N3C4=C(C(=CC=C4)OC)N=C3C(F)F)N5CCOCC5

2-((4-(4-(2-(difluoromethyl)-4-methoxy-1H-benzo[d]imidazol-1-yl)-6-morpholino-1,3,5-triazin-2-yl)piperazin-1-yl)sulfonyl)-N,N-dimethylethan-1-amine

(-20℃)

With Ice Pack

≥ 2 years