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Caroverine HCL
CAS No. 55750-05-5
Caroverine HCL ( —— )
产品货号. M24545 CAS No. 55750-05-5
Caroverine HCL 是一种有效的、竞争性的、可逆的 NMDA 和 AMPA 谷氨酸受体拮抗剂。它也是一种抗氧化剂和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥392 | 有现货 |
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| 10MG | ￥630 | 有现货 |
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| 25MG | ￥1274 | 有现货 |
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| 50MG | ￥2158 | 有现货 |
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| 100MG | ￥3537 | 有现货 |
|
| 200MG | ￥5067 | 有现货 |
|
| 500MG | ￥7641 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥432 | 有现货 |
|
生物学信息
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产品名称Caroverine HCL
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Caroverine HCL 是一种有效的、竞争性的、可逆的 NMDA 和 AMPA 谷氨酸受体拮抗剂。它也是一种抗氧化剂和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。
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产品描述Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It?is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and?can be used for the research of inner ear tinnitus.
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体外实验Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) andnoradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.
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体内实验Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat. Animal Model:Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure Dosage:1.44 mg/rat Administration:20 mg/mL; s.c. 1.0 mL/h for 72 h Result:Significantly protected the cochlea against impulse noise trauma.
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同义词——
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通路Neuroscience
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靶点GluR
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受体AMPA|NMDA
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研究领域——
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适应症——
化学信息
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CAS Number55750-05-5
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分子量401.9
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分子式C22H28ClN3O2
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (248.80 mM; Need ultrasonic)
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SMILESO=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ishida Y, et, al. Vasorelaxant action of caroverine fumarate (a quinoxaline derivative), a calcium-blocking agent. Br J Pharmacol. 1980;71(1):343-8.
