Caroverine HCL

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Caroverine HCL 是一种有效的、竞争性的、可逆的 NMDA 和 AMPA 谷氨酸受体拮抗剂。它也是一种抗氧化剂和钙阻滞剂，具有血管舒张作用，可用于内耳耳鸣的研究。

Caroverine HCL is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It?is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, and?can be used for the research of inner ear tinnitus.

Caroverine (1 μM; pretreated for 10 min) inhibits the pressor response to KCl (80 mM) andnoradrenaline (1 μM) in the rat hindquarter preparation. Caroverine markedly suppresses the contraction caused by KCl (40 mM) in the rat isolated aorta.

Caroverine (1.44 mg/rat; s.c; 1.0 mL/h for 72 h) attenuates impulse noise-induced hearing loss in the rat. Animal Model:Sprague-Dawley rats of either sex (250-300 g) received impulse noise exposure Dosage:1.44 mg/rat Administration:20 mg/mL; s.c. 1.0 mL/h for 72 h Result:Significantly protected the cochlea against impulse noise trauma.

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Neuroscience

GluR

AMPA|NMDA

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55750-05-5

401.9

C22H28ClN3O2

>98% (HPLC)

DMSO:100 mg/mL (248.80 mM; Need ultrasonic)

O=C1N(CCN(CC)CC)C2=C(C=CC=C2)N=C1CC3=CC=C(OC)C=C3.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years