5-hydroxytryptamine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-羟色胺是来自动物的天然产物。

5-hydroxytryptamine is a natural product from animals.

Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki=?44 μM). Results show that addition of 100 μM of Serotonin decreases the reaction velocity of COMT.

Serotonin produces robust hypersensitivity compare to saline-treated controls (p<0.001). A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin compare to IL-13-/- receiving vehicle following induction of DSS colitis.

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Others

Other Targets

Others

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50-67-9

176.22

C10H12N2O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (567.47 mM)

NCCc1c[nH]c(cc2)c1cc2O

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(-20℃)

With Ice Pack

≥ 2 years