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Hexahydrocurcumin
CAS No. 36062-05-2
Hexahydrocurcumin ( —— )
产品货号. M24319 CAS No. 36062-05-2
六氢姜黄素是一种选择性、口服活性 COX-2 抑制剂，对 COX-1 无活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2261 | 有现货 |
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| 10MG | ￥3506 | 有现货 |
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| 25MG | ￥5506 | 有现货 |
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| 50MG | ￥7421 | 有现货 |
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| 100MG | ￥9630 | 有现货 |
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| 200MG | ￥13050 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ￥3002 | 有现货 |
|
生物学信息
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产品名称Hexahydrocurcumin
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述六氢姜黄素是一种选择性、口服活性 COX-2 抑制剂，对 COX-1 无活性。
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产品描述Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.
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体外实验Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) treatment significantly decreased the viability of HT-29 colon cancer cells in a time- and concentration-dependent. The respective IC50 values for 24 and 48 h of Hexahydrocurcumin exposureare 77.05 and 56.95, respectively.Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 expression. The level of COX-1 is not altered.Hexahydrocurcumin (0-25 μM; 24-48 hours; HT-29 cells) combined with 5-fluorouracil (5-FU; 5 μM) markedly reduces the COX-2 protein. The level of COX-1 protein is not altered.Hexahydrocurcumin (7-14 μM; 24 hours) attenuates lipopolysaccharide (LPS)-elicited increase of prostaglandin E2 (PGE2) in murine macrophages (RAW 264.7) in a concentration-dependent manner. Cell Viability Assay Cell Line:HT-29 cells Concentration:0 μM, 5 μM, 10 μM, 25 μM Incubation Time:24 hours or 48 hours Result:Significantly decreased the viability of HT-29 colon cancer cells.RT-PCR Cell Line:HT-29 cells Concentration:25 μM Incubation Time:24 hours Result:Combined with 5-fluorouracil (5-FU; 5 μM) markedly reduced the COX-2 expression.Western Blot Analysis Cell Line:HT-29 cells Concentration:25 μM Incubation Time:24 hours Result:Combined with 5-fluorouracil (5-FU; 5 μM) markedly reduced the COX-2 protein.
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体内实验Hexahydrocurcumin (50 mg/kg; oral administration; daily; for 16 weeks; male Wistar rats) treatment significantly reduces the numbers of aberrant crypt foci (ACF) in colon cancer rats. Hexahydrocurcumin also markedly decreases COX-2 protein expression. The levels of COX-1 protein is not different from normal rats. Animal Model:Male Wistar rats (100-120 g) injected with dimethylhydrazine (DMH) Dosage:50 mg/kg Administration:Oral administration; daily; for 16 weeks Result:Significantly reduced the numbers of ACF in colon cancer rats. Also markedly decreased COX-2 protein expression.
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同义词——
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通路Chromatin/Epigenetic
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靶点COX
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受体COX-1|ROS
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研究领域——
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适应症——
化学信息
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CAS Number36062-05-2
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分子量374.43
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分子式C21H26O6
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纯度>98% (HPLC)
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溶解度DMSO:45 mg/mL (120.19 mM; Need ultrasonic)
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SMILESO=C(CC(O)CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Srimuangwong K, et al. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9.
