XMD-17-51 Trifluoroacetate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

XMD-17-51 三氟乙酸盐是一种有效且高选择性的 NUAK1 抑制剂。

XMD-17-51 Trifluoroacetate is a potent and highly selective NUAK1 inhibitor.

XMD-17-51 TFA is a pyrimido-diazepinone compound that is able to modulate protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1, 2, 3, or 4, Ack1, Ack2, Abl, DCAMKL1, ABL1, Abl mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK, ULK2, PLK, PRKD1, PRKD2, PRKD3, ROS1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, Axl, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rsk1, SGK, TrkA, TrkB and TrkC, and can be used in the treatment of various diseases, disorders or conditions.

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XMD-17-51 Trifluoroacetate (1628614-50-5 free base)

Membrane Transporter/Ion Channel

AMPK

NUAK1

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2436579-93-8

518.49

C23H25F3N8O3

>98% (HPLC)

DMSO:80 mg/ml (197.78 mM); Ethanol:8 mg/ml (19.78 mM); Water:2 mg/ml (4.94 mM)

O=C1N(C)C2=CN=C(NC3=CN(C4CCNCC4)N=C3)N=C2N(C)C5=CC=CC=C15.FC(C(O)=O)(F)F

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(-20℃)

With Ice Pack

≥ 2 years