Ampkinone

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ampkinone 是一种新型的 AMPK 小分子激活剂，通过间接激活各种细胞系中的 AMPK 来刺激 AMPK 磷酸化。

Ampkinone is a novel small molecule activator of AMPK, stimulates the phosphorylation of AMPK via indirect activation of AMPK in various cell lines (2.7-fold at 10 uM); Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake in muscle cells; significantly reduces total body weight and overall fat mass in DIO mice, effectively improves metabolic abnormalities in the DIO mice model.

Ampkinone stimulates the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK requires the activity of LKB1 and results in increased glucose uptake inmuscle cells.

Ampkinone-treated DIO mice significantly reduce total body weight and overall fat mass. Histological examination and measurement of lipid parameters show that Ampkinone effectively improves metabolic abnormalities in the DIO mice model.

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Membrane Transporter/Ion Channel

AMPK

AMPK

Metabolic Disease

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1233082-79-5

505.5174

C31H23NO6

>98% (HPLC)

10 mM in DMSO

CC1(C2=C(C=CC3=C2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)C5=CC=CC=C5)C6=C(O1)C(=C(C=C6)OC)O)C

[1]Benzopyrano[3,4-e]isoindole-1,3(2H,4H)-dione, 2-(4-benzoylphenyl)-6-hydroxy-7-methoxy-4,4-dimethyl-

(-20℃)

With Ice Pack

≥ 2 years