SCR130

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-氯苯基)-8-thioxo- 具有酶抑制、抗增殖作用和抗真菌活性。

1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo- is enzyme inhibition, antiproliferative effects and antifungal activity.

SCR130 (7-21 μM; 48 hours) increase in the number of late and early apoptotic cells. SCR130 induces apoptosis by both intrinsic and extrinsic pathways. SCR130 increases the expression of p-p53, BCL2 and MCL1, and CYTOCHROME C, BAX, and BAK also increaseed. The activation of caspase 8, increase in expression of FAS and SMAC-DIABLO proteins are also observed.SCR130 (48 hours) exhibits cytotoxicity in Reh, HeLa, CEM, Nalm6, and N114 cells with IC50 values of 14.1 μM, 5.9 μM, 6.5 μM, 2.2 μM, and 11 μM, respectively.SCR130 can potentiate the effect of radiation (0.5 and 1 Gy) by inducing enhanced cell death upon coadministration in Reh and Nalm6 cell lines.SCR130 blocks the endogenous NHEJ leading to accumulation of unrepaired DNA breaks. Treatment with SCR130 leads to inhibition of endogenous NHEJ, resulting in the accumulation of DNA double-strand breaks (DSBs) and cell death by activating apoptotic pathways.:Apoptosis Analysis Cell Line:Reh cells Concentration:7 μM, 14 μM, and 21 μM Incubation Time:48 hours Result:Showed a concentration-dependent increase in the number of late and early apoptotic cells.Western Blot Analysis Cell Line:Reh cells Concentration:7 μM, 14 μM, and 21 μM Incubation Time:48 hoursResult:Revealed a concentration-dependent increase in levels of pATM and activation of p53 through phosphorylation.

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1,7,9-Triazaspiro[4.5]dec-1-ene-6,10-dione, 2,4-bis(4-chlorophenyl)-8-thioxo-

Others

Other Targets

Others

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2377858-38-1

418.3

C19 H13 Cl2 N3 O2 S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (239.06 mM)

O=C(NC(NC1=O)=S)C21C(C3=CC=C(Cl)C=C3)CC(C4=CC=C(Cl)C=C4)=N2

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(-20℃)

With Ice Pack

≥ 2 years