Selective, high affinity, non-competitive α1A adrenoceptor antagonist (Ki = 0.35 nM). Exhibits no significant activity against a range of other GPCRs, including α2A, β1 and β2 adrenoceptors. Antagonizes effects of phenylephrine on isolated rabbit prostate muscle in vitro and on intra-urethral pressure in rats.

Semilicoisoflavone B can inhibit sorbitol formation of rat lens incubated with a high concentration of glucose, indicates that it may be effective for preventing osmotic stress in hyperglycemia.

Brevinin - 1