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ACBI1
CAS No. 2375564-55-7
ACBI1 ( —— )
产品货号. M24091 CAS No. 2375564-55-7
ACBI1 是 BAF ATPase 亚基 SMARCA2 和 SMARCA4 的有效 PROTAC 降解剂，还可降解多溴相关 BAF (PBAF) 复合体成员 PBRM1，MV-4-中 SMARCA2、SMARCA4 和 PBRM1 的 DC50 分别为 6 nM、11 nM 和 32 nM分别为 11 个单元。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2309 | 有现货 |
|
| 10MG | ￥3686 | 有现货 |
|
| 25MG | ￥5794 | 有现货 |
|
| 50MG | ￥7961 | 有现货 |
|
| 100MG | ￥10350 | 有现货 |
|
| 500MG | ￥20610 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ACBI1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ACBI1 是 BAF ATPase 亚基 SMARCA2 和 SMARCA4 的有效 PROTAC 降解剂，还可降解多溴相关 BAF (PBAF) 复合体成员 PBRM1，MV-4-中 SMARCA2、SMARCA4 和 PBRM1 的 DC50 分别为 6 nM、11 nM 和 32 nM分别为 11 个单元。
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产品描述ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
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体外实验ACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity.ACBI1 (0.3 μM; 100 h) induces apoptosis in SK-MEL-5 cells.ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. Cell Proliferation Assay Cell Line:MV-4-11, NCI-H1568 cells Concentration:0-1000 nM Incubation Time:3-7 days Result:Showed anti-proliferative activity with IC50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively.Apoptosis Analysis Cell Line:SK-MEL-5 cells Concentration:0.3 μM Incubation Time:100 hResult:Induced apoptosis in SK-MEL-5 cells.
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体内实验——
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同义词——
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通路Apoptosis
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靶点Apoptosis
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受体Apoptosis|Epigenetic Reader Domain|PROTAC
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研究领域——
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适应症——
化学信息
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CAS Number2375564-55-7
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分子量936.1
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分子式C49H58FN9O7S
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纯度>98% (HPLC)
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溶解度DMSO:100 mg/mL (106.83 mM)
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SMILESCC(N=CS1)=C1C2=CC=C(CNC([C@@H]3C[C@@H](O)CN3C([C@H](C(C)(C)C)NC(C4(CC4)F)=O)=O)=O)C(OCCOC5=CC=C(CN6CCN(C7=CC(C8=C(O)C=CC=C8)=NN=C7N)CC6)C=C5)=C2
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
产品手册
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