UUN44923

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UUN44923 是一种 FTO 抑制剂。它可能有助于治疗相关疾病。 FTO的目标包括肥胖、代谢综合征(MS)、2型糖尿病(T2D)、阿尔茨海默病、乳腺癌、小细胞肺癌、人骨髓横纹肌癌、胰腺癌、恶性胶质母细胞瘤等。

UUN44923 is a FTO inhibitor.?It may be useful for treating diseases assocd.?with FTO targets, obesity, metabolic syndrome (MS) , type 2 diabetes (T2D) , Alzheimer's diseases, breast cancers, small- cell lung cancers, a human bone marrow striated muscle cancer, a pancreatic cancer, malignant glioblastoma and the like.?

FTO-IN-1 (50 μM) inhibits FTO enzyme activity by 62% in vitro.FTO-IN-1 (50 μM) inhibits the viability of SCLC-21H, RH30 and KP3 cells, with IC50s of 2.1 μM, 5.3 μM, and 5.6 μM, respectively.

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FTO-IN-1

Others

Other Targets

FTO

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2243944-92-3

391.25

C18H16Cl2N4O2

>98% (HPLC)

DMSO:80 mg/mL (199.79 mM);Ethanol:80 mg/mL (199.79 mM)

O=C(NO)C1=CC=CC=C1NC2=C(Cl)C=C(C3=C(C)NN=C3C)C=C2Cl

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(-20℃)

With Ice Pack

≥ 2 years