021-51111890
购物车（）
sales@molnova.cn
GSK620
CAS No. 2088410-46-0
GSK620 ( —— )
产品货号. M23936 CAS No. 2088410-46-0
GSK620是一种泛BD2抑制剂，在人全血中显示出抗炎表型，具有优异的广泛选择性、可开发性和体内口服药代动力学。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥440 | 有现货 |
|
| 10MG | ￥696 | 有现货 |
|
| 25MG | ￥1367 | 有现货 |
|
| 50MG | ￥2037 | 有现货 |
|
| 100MG | ￥2871 | 有现货 |
|
| 200MG | ￥4113 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥472 | 有现货 |
|
生物学信息
-
产品名称GSK620
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述GSK620是一种泛BD2抑制剂，在人全血中显示出抗炎表型，具有优异的广泛选择性、可开发性和体内口服药代动力学。
-
产品描述GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD2 family of proteins, with >200-fold selectivity over all other bromodomains. GSK620 shows an anti-inflammatory phenotype in human whole blood.
-
体外实验——
-
体内实验——
-
同义词——
-
通路Chromatin/Epigenetic
-
靶点Epigenetic Reader Domain
-
受体pan-BD2
-
研究领域——
-
适应症——
化学信息
-
CAS Number2088410-46-0
-
分子量325.4
-
分子式C18H19N3O3
-
纯度>98% (HPLC)
-
溶解度DMSO:62.5 mg/mL (192.09 mM; Need ultrasonic)
-
SMILESCNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Seal JT, et al. The Optimization of a Novel, Weak Bromo and Extra Terminal Domain (BET) Bromodomain Fragment Ligand to a Potent and Selective Second Bromodomain (BD2) Inhibitor. J Med Chem. 2020;63(17):9093-9126.
产品手册
关联产品
-
Curcumin
姜黄素是一种天然酚类化合物，具有令人印象深刻的抗氧化特性。最近证明姜黄素部分通过激活核因子（红细胞 2 相关）因子 2 (Nrf2) 发挥其化学预防作用。
-
GSK778 hydrochloride
GSK778 hydrochloride hydrochloride is a potent and selective BD1 bromodomain inhibitor of the BET proteins, with IC50s of 75 nM (BRD2 BD1), 41 nM (BRD3 BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. GSK778 hydrochloride hydrochloride phenocopies the effects of pan-BET inhibitors in cancer models.
-
NEO2734
NEO2734 是一种口服活性、选择性的 p300/CBP 和 BET 溴结构域抑制剂（p300/CBP 和 BET 溴结构域的 IC50 均<30 nM）。
