GET73

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GET73 是 mGluR5 的负变构调节剂。 GET73 是一种天然存在的神经递质。 GET73 具有抗酒精和抗焦虑特性。

GET73 is an negative allosteric modulator of mGluR5. GET73 is a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties.

GET73 (1 μM, 10 μM; 1 hour) 1 hour before and during chronic ethanol exposure prevents ethanol-induced a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production. Cell Viability Assay Cell Line:Rat hippocampal neurons Concentration:0.1 μM, 1 μM, 10 μM Incubation Time:1 hour Result:Prevented the ethanol (75 mM, 4 days) -induced MTT reduction.

GET73 (5–50?mg/kg; i.g.) exerts an anxiolytic effect in Sprague-Dawley rats exposed to the elevated plus maze (EPM) test. Animal Model:Male SD rats (200-300?g and 300–350?g)Dosage:5 mg/kg, 10 mg/kg, 25 mg/kg, 50 mg/kg Administration:Oral gavage Result:Exerted an anxiolytic effect in rats exposed to the elevated plus maze (EPM) test.

Gamma hydroxybutyric acid analogue | GET 73

Neuroscience

GluR

mGluR5

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202402-01-5

275.27

C13H16F3NO2

>98% (HPLC)

DMSO:97 mg/mL?(352.38 mM;?Need ultrasonic)

COCCCC(NCc1ccc(C(F)(F)F)cc1)=O

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(-20℃)

With Ice Pack

≥ 2 years