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VU0650786
CAS No. 1809085-30-0
VU0650786 ( —— )
产品货号. M23823 CAS No. 1809085-30-0
VU0650786 是一种选择性、有效的 CNS 渗透性负变构调节剂，代谢型谷氨酸受体亚型 3 (mGlu3 NAM) (IC50: 392 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2356 | 有现货 |
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| 10MG | ￥3306 | 有现货 |
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| 25MG | ￥5171 | 有现货 |
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| 50MG | ￥7031 | 有现货 |
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| 100MG | ￥8883 | 有现货 |
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| 200MG | ￥12330 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2014 | 有现货 |
|
生物学信息
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产品名称VU0650786
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述VU0650786 是一种选择性、有效的 CNS 渗透性负变构调节剂，代谢型谷氨酸受体亚型 3 (mGlu3 NAM) (IC50: 392 nM)。
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产品描述VU0650786 is a selective and potent CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM) (IC50: 392 nM), with antidepressant and anxiolytic activity in rodents.
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体外实验——
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体内实验VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice.The pharmacokinetic parameters of VU0650786 (compound 106) in rats.
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同义词——
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通路Neuroscience
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靶点GluR
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受体mGluR3
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研究领域——
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适应症——
化学信息
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CAS Number1809085-30-0
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分子量387.8
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分子式C18H15ClFN5O2
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纯度>98% (HPLC)
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溶解度DMSO: 240 mg/mL (618.88 mM; Need ultrasonic);H2O: insoluble
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SMILESClC1=CN=C(OCC2=NN([C@H](C)CN(C3=C(F)N=CC=C3)C4=O)C4=C2)C=C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.
