SAR7334

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SAR7334 是一种有效且特异性的 TRPC6 抑制剂（IC50 为 7.9 nM）。

SAR7334 is a potent and specific inhibitor of TRPC6(IC50 of 7.9 nM).

SAR7334 inhibits TRPC6, TRPC3 and TRPC7-mediated Ca2+ influx into cells with IC50s of 9.5, 282 and 226?nM, whereas TRPC4 and TRPC5-mediated Ca2+ entry is not affected. SAR7334 (1?μM) results in a major block of the Ang II-evoked calcium influx in the podocytes. SAR7334 (1 μM) has negligible effect on SOCE. SAR7334 dose-dependently reduces TRPC6 currents with an IC50 of 7.9?nM. SAR7334 (100?nM) substantially reduces TRPC6 currents.

SAR7334 (10?mg/kg, p.o.) suppresses TRPC6-dependent acute HPV in isolated perfused lungs from mice. SAR7334 demonstrates that it is suitable for chronic oral administration. In an initial short-term study, SAR7334 does not change mean arterial pressure in spontaneously hypertensive rats (SHR).

TRCP6-IN-1

Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRPC6

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1333210-07-3

367.87

C21H22ClN3O

>98% (HPLC)

DMSO:350 mg/mL (951.42 mM)

N[C@H](CCC1)CN1[C@H](Cc1c2cccc1)[C@@H]2Oc(ccc(C#N)c1)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years