Naftopidil hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Naftopidil Hydrochloride 是一种选择性 α1-肾上腺素受体拮抗剂，对克隆人 α1a-肾上腺素受体、α1b-肾上腺素受体和 α1d-肾上腺素受体的 Ki 值分别为 3.7 nM、20 nM 和 1.2 nM。

Naftopidil hydrochloride is a selective alpha1-adrenoceptor antagonist with Ki of 3.7 nM, 20 nM and 1.2 nM for the cloned human α1a-adrenoceptor, α1b-adrenoceptor and α1d-adrenoceptor, respectively. Naftopidil hydrochloride has antiproliferative effects.

Naftopidil hydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma.Naftopidil hydrochloride (10 μM for PCa cells, 0.1-10 μM for PrSC; 3 days) shows growth inhibitory effects on PCa cells and PrSC.Naftopidil hydrochloride (50 μM for E9 cells, 25 μM for PrSC; 48 hours) increases the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC. Cell Proliferation Assay Cell Line:PCa cells, PrSC Concentration:10 μM (PCa cells); 0.1 μM, 1 μM, 10 μM (PrSC) Incubation Time:3 days Result:Exhibited growth inhibitory effects on PCa cells and PrSC in dose-dependent manners.Western Blot Analysis Cell Line:PCa cells, PrSC Concentration:50 μM (E9 cells), 25 μM (PrSC)Incubation Time:48 hours Result:Increased the level of cell-cycle regulatory protein p27 in E9 cells, but not PrSC.

Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model. Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft Dosage:10 mg/kg Administration:Oral administration, daily, for 28 days Result:Decreased tumor weights.

KT-611 hydrochloride | BM-15275 hydrochloride | 1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-

Apoptosis

Adenosine Receptor

α1-adrenoceptor

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1164469-60-6

428.95

C24H29ClN2O3

>98% (HPLC)

——

OC(COC1=C2C=CC=CC2=CC=C1)CN3CCN(C4=CC=CC=C4OC)CC3.[H]Cl

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(-20℃)

With Ice Pack

≥ 2 years