Cinobufotalin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cinobufotalin 是蟾蜍的主要心脏毒素，是一种新型抗 HCC 药物，它通过神经酰胺的产生诱导培养的 HCC 细胞生长抑制和凋亡。

Cinobufotalin is a main cardiac toxin in toad, it is a novel anti-HCC agent, it induces growth inhibition and apoptosis in cultured HCC cells through ceramide production. Cinobufotalin is also an effective reversal agent for the multidrug resistance of tumors, it can reverse the adriamycin-resistance in Raji/ADR cells and the expression of P-gp and MRP-1 proteins. Cinobufotalin can promote the dendritic cells(DCs) derived from peripheral blood of patients with chronic hepatitis B to mature and effectively enhance its(the DCs') capabilities, therefore the treatment of cinobufotalin may potentiate the antiviral immunity of the patients with chronic hepatitis B(CHB).

Cell Cytotoxicity Assay Cell Line:A549, H460 and HTB-58 human lung cancer cells Concentration:0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM Incubation Time:72 hours Result:Significantly induced cell death in a concentration-dependent manner.

Animal Model:Male nude mice (4-6 weeks old, BALB/c) with A549 cells Dosage:1 mg/kg or 5 mg/kg Administration:Intraperitoneal injection; twice daily; for 1 weeks Result:Inhibited A549 lung cancer cell growth in vivo.

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Cytoskeleton/Cell Adhesion Molecules

Akt

Akt|IL Receptor|MRP1|P-gp

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1108-68-5

458.54

C26H34O7

>98% (HPLC)

DMSO:35 mg/mL (76.33 mM)

C[C@]([C@@H](C(C=C1)=COC1=O)[C@H]2OC(C)=O)(CC[C@@]3([H])[C@@]4([H])CC[C@@]5(O)[C@@]3(CC[C@H](O)C5)C)[C@@]64[C@@H]2O6

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(-20℃)

With Ice Pack

≥ 2 years