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Borussertib
CAS No. 1800070-77-2
Borussertib ( Borussertib )
产品货号. M12732 CAS No. 1800070-77-2
Borassertib 是一种有效的、一流的共价变构 AKT 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥1482 | 有现货 |
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| 5MG | ￥2461 | 有现货 |
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| 10MG | ￥3772 | 有现货 |
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| 25MG | ￥6305 | 有现货 |
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| 50MG | ￥8547 | 有现货 |
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| 100MG | ￥11070 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2546 | 有现货 |
|
生物学信息
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产品名称Borussertib
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Borassertib 是一种有效的、一流的共价变构 AKT 抑制剂。
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产品描述Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor; specifically binds to two non-catalytic cysteines in AKT at 120 positions 296 and 310; exhibits pronounced sensitivity to breast cancer cell line ZR-75-1 with EC50 of 5 nM, 7- to 12-fold higher potency compared to reversible allosteric inhibitor miransertib and MK-2206; demonstrated strong antiproliferative activity in cancer cell lines harboring genetic alterations within the PTEN, PI3K, and RAS signaling pathways,b displayed antitumor activity in combination with the MEK inhibitor trametinib in patient-derived xenograft models of mutant KRAS pancreatic and colon cancer.
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体外实验——
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体内实验——
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同义词Borussertib
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通路Cytoskeleton/Cell Adhesion Molecules
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靶点Akt
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受体Akt
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研究领域——
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适应症——
化学信息
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CAS Number1800070-77-2
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分子量596.691
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分子式C36H32N6O3
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 25 mg/mL (41.90 mM)
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SMILESC=CC(NC1=CC=C(C(N2C3CCN(CC4=CC=C(C5=NC6=C(C(NC=C6)=O)C=C5C7=CC=CC=C7)C=C4)CC3)=C1)NC2=O)=O
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化学全称N-(2-oxo-3-(1-(4-(5-oxo-3-phenyl-5,6-dihydro-1,6-naphthyridin-2-yl)benzyl)piperidin-4-yl)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)acrylamide
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Weisner J, et al. Cancer Res. 2019 Mar 11. pii: canres.2861.2018.
