SCH 442416

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SCH-442416 是腺苷 A2A 受体的选择性拮抗剂。 SCH-442416 以高亲和力与人和大鼠 A2A 受体结合（Ki 值分别为 0.048 和 0.5 nM）。A2A 受体拮抗剂 (SCH 442416) 可以增加 Müller 细胞中 Kir 2.1 和 Kir 4.1 通道的 mRNA 表达，以保护缺氧条件下的体外视网膜神经元。

SCH-442416 is an selective antagonist of adenosine A2A receptor.?SCH-442416 binds to human and rat A2A receptors with high affinity (Ki values are 0.048 and 0.5 nM respectively).The A2A receptor antagonist (SCH 442416) could increase mRNA expression of the Kir 2.1and Kir 4.1 channels in Müller cells to protect the retinal neurons in vitro under hypoxic conditions.

SCH442416 is selective for A2AR (Ki=0.50 nM) in rat striatal membranes over A1R and A3R (Ki=1815 and >10000, respectively).SCH442416 (0.1-10?μM) increases the glutamine synthetase (GS) and glutamate aspartate transporter (GLAST) proteins expression of Müller cells in Group 1?μM.

SCH-442416 (0.017 mg/kg; i.p.) completely abrogates the CGS-21680-induced decrease in skeletal muscle injury.SCH-442416 (1 μM?2μL; i.v.) increases the GS and GLAST protein expression in rats.SCH442416 (1 μM) significantly attenuates the adenosine-induced dilation (from 15.3 to 5.6 μm).

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Apoptosis

Adenosine Receptor

A2A

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316173-57-6

389.42

C20H19N7O2

>98% (HPLC)

DMSO:Soluble

COc1ccc(cc1)CCCn2c3c(cn2)c4nc(nn4c(n3)N)c5ccco5

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(-20℃)

With Ice Pack

≥ 2 years