Homoeriodictyol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Homoeriodictyol 是一种天然存在的、掩盖苦味的黄烷酮，是一种很有前景的增加食欲和食物摄入量的化合物。在分化的 Caco-2 细胞中，黄烷酮高圣油酚可以增加 SGLT-1 介导的葡萄糖摄取，但减少血清素释放。与其他多酚相比，黄烷酮高圣油酚在 100 μM 浓度下可促进葡萄糖摄取 29.0 ± 3.83%。

Homoeriodictyol, a naturally occurring, bitter-masking flavanone, as a promising agent to increase appetite and food intake. The flavanone homoeriodictyol can increase SGLT-1-mediated glucose uptake but decrease serotonin release in differentiated Caco-2 cells.In contrast to other polyphenols, the flavanon Homoeriodictyol promotes glucose uptake by 29.0 ± 3.83% at a concentration of 100 μM. The glucose uptake stimulating effect was sensitive to phloridzin, but not to phloretin, indicating an involvement of the sodium-coupled glucose transporter SGLT-1, but not of sodium-independent glucose transporters (GLUT). In addition, in contrast to the increased extracellular serotonin levels by stimulation with 500 mM D-(+)-glucose, treatment with 100 μM Homoeriodictyol decreased serotonin release by -48.8 ± 7.57% in Caco-2 cells via a phloridzin-sensitive signaling pathway. Extracellular serotonin levels were also reduced by -57.1 ± 5.43% after application of 0.01 μM Homoeriodictyol to human neural SH-SY5Y cells.

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Endocrinology/Hormones

5-HT Receptor

GLUT|5-HT Receptor|Sodium Channel

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446-71-9

302.28

C16H14O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (165.41 mM)

O=C1C[C@@H](C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13

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(-20℃)

With Ice Pack

≥ 2 years