Chebulagic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Chebulagic Acid 是从 Terminalia chebula Retz 中分离出来的，是一种 COX-LOX 双重抑制剂。Chebulagic Acid 可以增强自噬，发挥抗炎和抗感染作用。

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Chebulagic acid can enhance autophagy and exerts anti-inflammatory and anti-infective effects. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+) - induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner.

Chebulagic acid can enhance the autophagy. Chebulagic acid exert anti-inflammatory and anti-infective effects. Chebulagic acid also shows a protective effect against 1-methyl-4-phenylpyridinium (MPP+)-induce cytotoxicity which mimics the pathological symptom of Parkinson's disease. Chebulagic acid inhibits the LPS-induced upregulation of TNF-α and IL-1β in a dose- and time-dependent manner. Furthermore, LPS-activated MAPK signaling is inhibited by Chebulagic acid treatment in the EA.hy926 cells.

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Chromatin/Epigenetic

COX

COX| LOX

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23094-71-5

954.66

C41H27O27

>98% (HPLC)

DMSO:98 mg/mL (102.66 mM; Need ultrasonic)

OC(CC(C(O[C@H]([C@@H](COC(C1=CC(O)=C2O)=O)O[C@@H]3OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@H](OC(C5=CC(O)=C(O)C(O)=C5C1=C2O)=O)[C@H]3OC6=O)=O)C(C7O)C(C6=CC(O)=C8O)=C8OC7=O)=O

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(-20℃)

With Ice Pack

≥ 2 years