Spaglumic acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Spaglumic Acid 是一种在大脑中以毫摩尔浓度存在的神经肽。Spaglumic Acid 通过 Ca2+ 依赖性过程去极化时释放，是 mGluR3 受体的激动剂和 NMDA 受体的拮抗剂。

Spaglumic acid is a neuropeptide found in millimolar concentrations in the brain.Spaglumic Acid is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes.

Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.

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NAAG,N-Acetylaspartylglutamic acid

Proteasome/Ubiquitin

Endogenous Metabolite

Human Endogenous Metabolite

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3106-85-2

304.26

C11H16N2O8

>98% (HPLC)

Water:29 mg/mL(95.31 mM)

CC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years