Exatecan Mesylate ( DX8951f )

产品货号. M22421 CAS No. 169869-90-3

Exatecan Mesylate 是一种 DNA 拓扑异构酶 I 抑制剂（IC50：2.2 μM，0.975 μg/mL）。Exatecan Mesylate (DX-8951f) 显着抑制多种癌细胞系的增殖，平均 GI50 为 2.02 ng/mL、2.92 ng/mL对于乳腺癌细胞、结肠癌细胞、胃癌细胞和肺癌细胞分别为 1.53 ng/mL 和 0.877 ng/mL。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥113	有现货
10MG	￥147	有现货
25MG	￥192	有现货
50MG	￥240	有现货
100MG	￥381	有现货
200MG	￥554	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥107	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Exatecan Mesylate
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Exatecan Mesylate 是一种 DNA 拓扑异构酶 I 抑制剂（IC50：2.2 μM，0.975 μg/mL）。Exatecan Mesylate (DX-8951f) 显着抑制多种癌细胞系的增殖，平均 GI50 为 2.02 ng/mL、2.92 ng/mL对于乳腺癌细胞、结肠癌细胞、胃癌细胞和肺癌细胞分别为 1.53 ng/mL 和 0.877 ng/mL。
产品描述

Exatecan Mesylate is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI50s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI50s of 0.186 and 0.395 ng/mL, respectively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells.Exatecan Mesylate (3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) highly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model.
体外实验

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体内实验

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同义词

DX8951f
通路

Cell Cycle/DNA Damage
靶点

Topoisomerase
受体

Topo I
研究领域

Cancer
适应症

Biliary cancer; Breast cancer; Cervical cancer; Ewing's sarcoma; Gastric cancer; Haematological malignancies; Liver cancer; Myelodysplastic syndromes; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Prostate cancer; Rhabdomyosarcoma; Solid tumours

化学信息

CAS Number

169869-90-3
分子量

531.55
分子式

C25H26FN3O7S
纯度

>98% (HPLC)
溶解度

DMSO:8 mg/mL (15.05 mM; Need ultrasonic);Water:6 mg/mL (11.29 mM; Need ultrasonic and warming)
SMILES

CS(O)(=O)=O.CC[C@@]1(O)C(=O)OCc2c1cc1-c3nc4cc(F)c(C)c5CC[C@H](N)c(c3Cn1c2=O)c45
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82.

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