Atezolizumab

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Atezolizumab 抗 PD-L1）是一种完全人源化 IgG1 单克隆抗体，可阻断 PD-L1 与 PD-1 和 B7.1 的相互作用，但不能阻断 PD-L2 与 PD-1 的相互作用。

Atezolizumab anti-PD-L1) is a fully humanized IgG1 monoclonal antibody that blocks the interaction of PD-L1 with both PD-1 and B7.1 but not the interaction of PD-L2 with PD-1.

Atezolizumab (0, 2.5, 5, 10, 20, and 40?μg/ml; 24 hours; HOS and 143B cells) inhibits proliferation and induces immune-independent apoptosis of osteosarcoma cells.Atezolizumab impairs the function of mitochondria to cause the imbalance between oxidants and antioxidants. Atezolizumab induces mitochondria-related apoptosis of osteosarcoma cells by activating JNK pathway. Atezolizumab (10?μg/ml; 24?hours; HOS and 143B cells) induces autophagy in osteosarcoma cells.

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Others

Other Targets

Other Targets

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1380723-44-3

145 kDa

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>98% (HPLC)

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(-20℃)

With Ice Pack

≥ 2 years