ML418

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML418 是一种有效的、选择性的、CNS 穿透性 Kir7.1 钾通道阻滞剂 (IC50 = 310 nM)，并且还有效抑制 Kir6.2/SUR1。

ML418 is a potent, selective and CNS penetrating Kir7.1 potassium channel blocker (IC50 = 310 nM), and also potently inhibits Kir6.2/SUR1.

ML418 has inhibitory activity for Kir7.1 dose-dependently with an IC50 value of 0.31 μM.ML418 has selectivity for Kir7.1 and Kir6.2/SUR1 with IC50 values of 1.3 μM and 1.9 μM, respectively.

ML418 (i.p.; 30 mg/kg) has good PK effect, excellent CNS penetration and favorable CNS distribution. Animal Model:Rats and Mice Dosage:30 mg/kg Administration:Intraperitoneal Result:Showed a suitable PK profile (Cmax = 0.20 μM and Tmax = 3 h), excellent CNS penetration with a mouse brain: Kp of 10.9, brain (323.9 ng/g): plasma (29.5 ng/mL).

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Cell Cycle/DNA Damage

Potassium Channel

Kir7.1

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1928763-08-9

377.87

C19H24ClN3O3

>98% (HPLC)

DMSO:20 mg/mL?(52.93 mM;?Need ultrasonic)

CC(C)OC(=O)NC1CCN(Cc2cc(Cl)c3cccnc3c2O)CC1

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(-20℃)

With Ice Pack

≥ 2 years