Gut restricted-7 ( GR-7 )

产品货号. M26241 CAS No. 2553218-46-3

Gut strict-7 (GR-7) 是一种共价且具有口服活性的泛胆盐水解酶 (BSH) 抑制剂。它可以减少肠道细菌 BSH 并降低小鼠粪便中解离胆汁酸的水平。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥3115	有现货
10MG	￥4418	有现货
25MG	￥6845	有现货
50MG	￥9235	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥3461	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

Gut restricted-7
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Gut strict-7 (GR-7) 是一种共价且具有口服活性的泛胆盐水解酶 (BSH) 抑制剂。它可以减少肠道细菌 BSH 并降低小鼠粪便中解离胆汁酸的水平。
产品描述

Gut restricted-7 (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.(In Vitro):Gut restricted-7 (60 μM) does not affect the epithelial barrier integrity of Caco-2 cells, suggesting that this compound is relatively nontoxic.?Gut restricted-7 also does not affect microbial biomass.(In Vivo):The C57BL/6 mice fed with either powdered chow containing 0.09% Gut restricted-7 (w/w) for 1 d day or powdered chow alone.?Gut restricted-7 significant inhibits the BSH activity in the feces of inhibitor-treated mice 8 h post-diet change.?20picomol/mg wet mass (~20 μM) of Gut restricted-7 in cecal contents is detected.
体外实验

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体内实验

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同义词

GR-7
通路

Cell Cycle/DNA Damage
靶点

Potassium Channel
受体

CDK1| CDK2| CDK3| CDK5
研究领域

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适应症

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化学信息

CAS Number

2553218-46-3
分子量

510.63
分子式

C25H40FNaO6S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 250 mg/mL (489.59 mM)
SMILES

O=C(CF)CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@H](OS(=O)(O[Na])=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1.McMillin DW, Delmore J, Negri J et al. Molecular and cellular effects of multi-targeted cyclin-dependent kinase inhibition in myeloma: biological and clinical implications. Br J Haematol. 2011 Feb;152(4):420-32.

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