Nepodin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nepodin 具有抗疟和抗炎活性，并显示出显着的环氧合酶 (COX) 抑制活性。

Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.To obtain a novel modulator of glucose metabolism, we conducted screening of a small compound library in cultured L6 myotubes. We identified Nepodin that stimulated glucose uptake dose-dependently in differentiated L6 myotubes. The stimulatory effect of Nepodin on glucose uptake was abrogated by a 5'-adenosine monophosphate-activated protein kinase (AMPK) inhibitor. In addition, Nepodin stimulated the phosphorylation of AMPK. Nepodin also stimulated the translocation of GLUT4 to the plasma membrane in L6 myoblasts transfected with a Glut4 cDNA-coding vector and in differentiated L6 myotubes. In in vivo study, Nepodin suppressed the increases in fasting blood glucose levels and improved the glucose intolerance of C57BL/KsJ-db/db mice, a type 2 diabetic animal model. Nepodin rescued the impaired phosphorylation of AMPK in the skeletal muscle of db/db mice.

Nepodin (Musizin) exhibits significant IC50 values that are 0.74 and 0.79 μg/ml against P. falciparum chloroquine-sensitive (3D7) and P. falciparum chloroquine-resistant (S20), respectively.

Nepodin (Musizin) (orally administration; 2-10 mg/kg; 4 weeks) improves the impaired glucose tolerance of db/db mice, also decreases an increase in plasma insulin concentration of db/db mice in a dose-dependent manner. Animal Model:C57BL/KsJ-db/db mice Dosage:2 mg/kg; 10 mg/kg Administration:Orally administration; 2-10 mg/kg; 4 weeks Result:Had antihyperglycemic potential and improved insulin resistance.

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Chromatin/Epigenetic

COX

COX|AMPK|GLUT

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3785-24-8

216.23

C13H12O3

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (578.09 mM)

CC(=O)C1=C(O)C2=C(C=CC=C2O)C=C1C

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(-20℃)

With Ice Pack

≥ 2 years