021-51111890
购物车（）
sales@molnova.cn
LASSBio-1135
CAS No. 852453-71-5
LASSBio-1135 ( —— )
产品货号. M21970 CAS No. 852453-71-5
LASSBio-1135是一种口服有效的TRPV1拮抗剂和TNF-α产生的抑制剂。口服100 mol x Kg(-1) LASSBio-1135可显着减少角叉菜胶引起的热痛觉过敏。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2119 | 有现货 |
|
| 10MG | ￥3192 | 有现货 |
|
| 25MG | ￥4985 | 有现货 |
|
| 50MG | ￥6817 | 有现货 |
|
| 100MG | ￥8883 | 有现货 |
|
| 200MG | ￥11970 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称LASSBio-1135
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述LASSBio-1135是一种口服有效的TRPV1拮抗剂和TNF-α产生的抑制剂。口服100 mol x Kg(-1) LASSBio-1135可显着减少角叉菜胶引起的热痛觉过敏。
-
产品描述LASSBio-1135 is an orally effective antagonist of TRPV1 and inhibitor of TNF-α production.Oral administration of 100 mol x Kg(-1) LASSBio-1135 markedly reduced thermal hyperalgesia induced by carrageenan, however at 10 mol x Kg(-1) only a partial reduction was observed at the 4th h. Neutrophil recruitment and TNF-α production after carrageenan stimulus was also inhibited by the treatment with LASSBio-1135.?Modulating TRPV1 and TNF-α production, two key therapeutic targets of neuropathic pain, 100 mol x Kg(-1) LASSBio-1135 was orally efficacious in reversing thermal hyperalgesia and mechanical allodynia produced by partial sciatic ligation 7-11 days after surgery without provoking hyperthermia, a common side effect of TRPV1 antagonists.?
-
体外实验——
-
体内实验——
-
同义词——
-
通路Membrane Transporter/Ion Channel
-
靶点TRP/TRPV Channel
-
受体TRPV1|TNF-α
-
研究领域——
-
适应症——
化学信息
-
CAS Number852453-71-5
-
分子量286.33
-
分子式C18H14N4
-
纯度>98% (HPLC)
-
溶解度——
-
SMILESN(c1c(nc2ccccn12)-c1ccccn1)c1ccccc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Lima C K F , Silva R M , Lacerda R B , et al. LASSBio-1135: A Dual TRPV1 Antagonist and Anti-TNF-Alpha Compound Orally Effective in Models of Inflammatory and Neuropathic Pain[J]. PLOS ONE, 2014, 9.
