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Butoconazole
CAS No. 64872-76-0
Butoconazole ( 1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole )
产品货号. M21968 CAS No. 64872-76-0
布托康唑是一种咪唑抗真菌剂布托康唑对体内白色念珠菌感染（小鼠）特别有效，在低至 0.25% 制剂强度时仍能保持良好的活性，并且在治疗结束后显示出异常低的再感染率。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥158 | 有现货 |
|
| 5MG | ￥243 | 有现货 |
|
| 10MG | ￥347 | 有现货 |
|
| 25MG | ￥554 | 有现货 |
|
| 50MG | ￥923 | 有现货 |
|
| 100MG | ￥1323 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Butoconazole
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述布托康唑是一种咪唑抗真菌剂布托康唑对体内白色念珠菌感染（小鼠）特别有效，在低至 0.25% 制剂强度时仍能保持良好的活性，并且在治疗结束后显示出异常低的再感染率。
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产品描述Butoconazole is an imidazole antifungal agentButoconazole is particularly effective against in vivo Candida albicans infections (mice), maintaining good activity down to 0.25% formulation strength and showing unusually low reinfection rates after treatment is ended.Butoconazole 1-BSR is an effective and safe alternative to longer-term therapy with miconazole nitrate (seven days) for vulvovaginal candidiasis.
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体外实验Imidazoles generally inhibit the conversion of lanosterol to ergosterol, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.
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体内实验——
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同义词1-[4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole
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通路Microbiology/Virology
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靶点Antifungal
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受体Antifungal
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研究领域——
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适应症——
化学信息
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CAS Number64872-76-0
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分子量411.76
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分子式C19H17Cl3N2S
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纯度>98% (HPLC)
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溶解度DMSO:77 mg/ml(187 mM)
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SMILESClc1ccc(CCC(Cn2ccnc2)Sc2c(Cl)cccc2Cl)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Walker K A M , Braemer A C , Hitt S , et al. 1-[4-(4-Chlorophenyl)-2-(2,6-dichlorophenylthio)-n-butyl]-1H-imidazole nitrate, a new potent antifungal agent[J]. Journal of Medicinal Chemistry, 1978, 21(8):840-843.2. Brown D , Henzl M R , Kaufman R H . Butoconazole nitrate 2% for vulvovaginal candidiasis. New, single-dose vaginal cream formulation vs. seven-day treatment with miconazole nitrate. Gynazole 1 Study Group[J]. Journal of Reproductive Medicine, 1999, 44(11):933-938.
产品手册
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