Stilbamidine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Stilbamidine 是 Stilbene 衍生的二脒化合物，主要以其羟乙基磺酸盐形式发挥作用，用于抑制各种真菌感染。

Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections.

The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine.[3H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC50=1.2 μM) or melarsen oxide (IC50=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC50=6.1 μM) and Stilbamidine (IC50=110 μM). The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence.

——

——

Microbiology/Virology

Antifungal

Antifungal

——

——

122-06-5

264.33

C16H16N4

>98% (HPLC)

——

N=C(N)C1=CC=C(C=CC2=CC=C(C=C2)C(=N)N)C=C1

——

(-20℃)

With Ice Pack

≥ 2 years