BI-409306

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BI-409306 是一种有效的选择性 PDE9A 抑制剂（IC50 为 52 nM），可用于记忆研究。

BI-409306 is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.(In Vitro):Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices.

Osoresnontrine is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 μM), PDE1C (IC50, 1.0 μM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 μM. Osoresnontrine enhances long-term potentiation (LTP) in rat hippocampal slices.

——

——

Angiogenesis

PDE

PDE9A

Nervous system

Alzheimer Disease

1189767-28-9

311.34

C16H17N5O2

>98% (HPLC)

DMSO:22 mg/ml(50.06 mM)

O=c1[nH]c(Cc2ccccn2)nc2n(ncc12)C1CCOCC1

——

(-20℃)

With Ice Pack

≥ 2 years