Dypyridamole

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

双嘧达莫（Persantine）是一种磷酸二酯酶抑制剂，可阻断红细胞和血管内皮细胞对腺苷的摄取和代谢。

Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.(In Vitro):Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells.Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells.Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation.(In Vivo):Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues.

Dipyridamole (5 μM; 15 min) results in a 2.5-fold increase in intracellular cAMP levels in OCI-AML-3 cells.Dipyridamole (5 μM; 48 h) with the statin combination induces apoptosis in primary AML cells.Dipyridamole (5 μM; 48 h) possesse cAMP/PKA-independent activity against statininduced SREBP2 activation. Apoptosis Analysis Cell Line:AML (OCI-AML-2, OCI-AML-3) cell line Concentration:5 μM Incubation Time:48 h Result:Induced apoptosis with the combination of fluvastatin and dipyridamole, cilostazol, forskolin, or dbcAMP in OCI-AML-2 and OCI-AML-3 cells.RT-PCRCell Line:LP1 cell line Concentration:5 μM Incubation Time:16 h Result:Increased the sensibility of cancer cells to statin-induced apoptosis.

Dipyridamole (10 mg/kg; p.o. once daily for 18 d) mitigates tumor growth, ameliorated concurrent alterations in blood circulation and tumor tissues, and platelet infiltration in tumor tissues. Animal Model:C57BL/6-LLC tumor-bearing mice models Dosage:10 mg/kg Administration:Oral gavage; 10 mg/kg; once daily for 18 days Result:Mitigated tumor growth in tumor-bearing mice.

NSC 515776 | NSC 619103

Angiogenesis

PDE

PDE| PDE

Cardiovascular Disease

——

58-32-2

504.63

C24H40N8O4

>98% (HPLC)

Ethanol: 50 mg/mL (99.08 mM); DMSO: 101 mg/mL (200.14 mM)

OCCN(CCO)C1=NC(N2CCCCC2)=C(N=C(N(CCO)CCO)N=C3N4CCCCC4)C3=N1

2,2',2'',2'''-((4,8-di(piperidin-1-yl)pyrimido[5,4-d]pyrimidine-2,6-diyl)bis(azanetriyl))tetraethanol

(-20℃)

With Ice Pack

≥ 2 years