14-Deoxy-1112-didehydroandrographolide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

14-Deoxy-11,12-didehydroandrographolide 具有降血压、抗炎、抗哮喘和抗癌作用。它可以抑制 NF-κB 的激活。

14-Deoxy-1112-didehydroandrographolide has hypotensive anti-inflammatory anti-asthma and anti-cancer actions. It can inhibit NF-κB activation.

14-deoxy-11,12-didehydroandrographolide, a naturally occurring noncytotoxic analogue of Andrographolide, effectively reduces Ovalbumin (OVA)-induced inflammatory cell recruitment into bronchoalveolar lavage (BAL) fluid, IL-4, IL-5, IL-13, and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion, mast cell degranulation, and airway hyper-responsiveness (AHR) in a mouse asthma model, probably via inhibition of NF-κB activity.

14-deoxy-11,12-didehydroandrographolide (1 mg/kg) dramatically reduces resistance (Rl) and restores Cdyn in OVA-challenged mice in response to methacholine.

14-dehydro Andrographolide | AP10

Apoptosis

NF-κB

NF-κB

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42895-58-9

332.43

C20H27O4

>98% (HPLC)

DMF: 100 mg/mL (300.82 mM; Need ultrasonic)

O=C1OCC=C1/C=C/[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@](O)CC[C@@]23C)=C

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(-20℃)

With Ice Pack

≥ 2 years