JSH-23

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JSH-23 是 NF-κB 转录活性的抑制剂，IC50 为 7.1 μM。

JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM.(In Vitro):JSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells.Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner.(In Vivo):JSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats.

JSH-2 (1-300 μM; 24 hours) at <100 μM does not show significant cytotoxic effects on the RAW 264.7 cells.Nuclear amount of NF-κB p65 is markedly increased upon exposure to LPS for 1 h. Treatment of JSH-23 (30 μM; 1 hours) to LPS- stimulated RAW 264.7 cells decreases nuclear content of NF-κB p65 in a dose-dependent manner.Cell Cytotoxicity Assay Cell Line:Macrophages RAW 264.7 Concentration:1, 3, 10, 30, 100, 300 μM Incubation Time:24 hours Result:Did not show significant cytotoxic effects at <100 μM.Western Blot Analysis Cell Line:Macrophages RAW 264.7 with LPS-stimulated Concentration:30 μM Incubation Time:1 hour Result:Decreased nuclear content of NF-κB p65 in a dose-dependent manner, corresponding to 49±4% inhibition at 3 μM, 75±7% at 10 μM and 95±8% at 30 μM.

JSH-23 (1 mg/kg, 3 mg/kg; orally administered; daily; for 2 weeks) significantly reverses the nerve conduction and nerve blood flow deficits seen in diabetic rats. Animal Model:Male Sprague Dawley diabetic rats (250-270 g)Dosage:1 mg/kg, 3 mg/kg Administration:Orally administered; daily; for 2 weeks Result:Produced significant improvement in motor nerve conduction velocity (MNCV).

NF-κB Activation Inhibitor II

Apoptosis

NF-κB

NF-κB

Cancer

——

749886-87-1

240.34

C16H20N2

>98% (HPLC)

Ethanol: 20 mg/mL (83.21 mM); DMSO: 48 mg/mL (199.71 mM)

NC1=CC(C)=CC=C1NCCCC2=CC=CC=C2

4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine

(-20℃)

With Ice Pack

≥ 2 years