Vardenafil hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Vardenafil dihydrochloride 是一种具有高选择性和口服活性的磷酸二酯酶 5 (PDE5) 抑制剂，IC50 为 0.7 nM。Vardenafil dihydrochloride 对 PDE1、PDE6 的 IC50 为 180 nM，11 nM，对 PDE3、PDE4 的 IC50 >1000 nM。Vardenafil dihydrochloride 非竞争性地抑制环磷酸鸟苷 (cGMP) 水解，从而提高 cGMP 水平。

Vardenafil hydrochloride is a New Phosphodiesterase Type 5(PDE5) Inhibitor in the Treatment of Erectile Dysfunction in Men With Diabetes.

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Animal Model:Male rat (9-week-old) underwent surgery for laparotomy or bilateral cavernous nerve (CN) crush injury.Dosage:0.03 mg/kg.Administration:Intravenous injectionResult:Restored normal erectile responses with a combind administration of BAY 60-4552 (0.03, 0.3 mg/kg).Animal Model:Liver injury induced by Con A in male Swiss albino mice (20 ± 2 g).Dosage:0.17 mg/kg.Administration:Intravenous injection; once daily, for 7 days; as a pretreatmentResult:Reduced the levels of serum transaminases and alleviated Con A-induced hepatitis.Animal Model:Male 7-week-old Zucker diabetic fatty (ZDF) rats (preserved ejection fraction, HFpEF) Dosage:10 mg/kg.Administration:Oral gavage; once daily, for 25 weeks Result:Improved myofilament function in diabetic rat hearts.

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Angiogenesis

PDE

PDE5

Metabolic Disease

Erectile Dysfunction

224785-91-5

525.06

C23H33ClN6O4S

>98% (HPLC)

DMSO:100 mg/mL (190.45 mM; Need ultrasonic); H2O:100 mg/mL (190.45 mM)

Cl.CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1

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(-20℃)

With Ice Pack

≥ 2 years