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PF-2545920 hydrochloride
CAS No. ——
PF-2545920 hydrochloride ( Mardepodect hydrochloride | MP-10 hydrochloride | PF-02545920 hydrochloride )
产品货号. M16961 CAS No. ——
一种有效的选择性 PDE10A 抑制剂，IC50 为 0.37 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 100MG | 获取报价 | 有现货 |
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| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称PF-2545920 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述一种有效的选择性 PDE10A 抑制剂，IC50 为 0.37 nM。
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产品描述A potent and selective PDE10A inhibitor with IC50 of 0.37 nM; displays >1,000-fold selectivity over the PDEs; antagonizes apomorphine-induced climbing in mice, inhibits conditioned avoidance responding in both rats and mice, and blocks NMDA antagonist-induced deficits in prepulse inhibition of acoustic startle response in rats; dose-dependently increases c-Fos immunopositive nuclei in all regions of neostriatum in the DRd1a-tdTomato mice; improves cortico-basal ganglia function in huntington's disease models; orally bioavailable.Schizophrenia Phase 2 Discontinued.
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体外实验——
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体内实验——
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同义词Mardepodect hydrochloride | MP-10 hydrochloride | PF-02545920 hydrochloride
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域——
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适应症——
化学信息
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CAS Number——
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分子量428.9135
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分子式C25H21ClN4O
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纯度>98% (HPLC)
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溶解度DMSO
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SMILES——
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化学全称Quinoline, 2-[[4-[1-methyl-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxy]methyl]-,hydrochloride(1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Verhoest PR, et al. J Med Chem. 2009 Aug 27;52(16):5188-96.
2. Grauer SM, et al. J Pharmacol Exp Ther. 2009 Nov;331(2):574-90.
3. Beaumont V, et al. Neuron. 2016 Dec 21;92(6):1220-1237.
产品手册
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