Hydroxy-?α-?sanshool

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

羟基-α-山椒素是从胡椒中分离出来的烷基酰胺。它充当 TRPA1 共价和 TRPV1 非共价激动剂（EC50：69 和 1.1 μM）。

Hydroxy-?α-?sanshool is an alkyl amide isolated from the pepper. It acts as a TRPA1 covalent and TRPV1 non-covalent agonist (EC50s: 69 and 1.1 μM).

Hydroxy-α-sanshool (0-10 mM; 20 s) induces inward currents in cultured DRG neuron.Hydroxy-α-sanshool (1 mM; 0-1 min) increases intracellular Ca2+ in cultured DRG neuron. Cell Viability Assay Cell Line:Dorsal root ganglion (DRG) neurons Concentration:0-10 mM Incubation Time:20 s Result:Induced small but robust inward currents for DRG neuron with an EC50 of 66.2 μM.Cell Viability Assay Cell Line:Dorsal root ganglion (DRG) neurons Concentration:1 mM Incubation Time:0-1 min Result:Led to an intracellular Ca2+ increase in the majority of DRG neurons tested (98 of 100).

Hydroxy-α-sanshool (intradermal injection; 4 mg per mouse; once) shows paw-licking response in wild-type and TRPV1-deficient mice.Hydroxy-α-sanshool (1 mM) ismarkedly aversive to WT mice, but in TRPV1 KO mice, the aversion is almost entirely eliminated (P<0.001). Animal Model:Wild-type and TRPV1-deficient mice Dosage:4 mg per mouse Administration:Intradermal injection; 4 mg per mouse; once Result:Reduced paw-licking response in TRPV1-deficient mice (160 times, P < 0.05).Showed paw-licking response in wild-type mice (mean 284.8 times) in 20 min.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRPA1| TRPV1

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83883-10-7

263.37

C16H25NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (379.68 mM)

CC(C)(CNC(/C=C/CC/C=C\C=C\C=C\C)=O)O

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(-20℃)

With Ice Pack

≥ 2 years