ICILIN

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Icilin(AG 3-5) 是一种合成的 TRPM8 离子通道超级激动剂。

Icilin(AG 3-5) is a synthetic super-agonist of TRPM8 ion channel.

Icilin-evoked TRPM8 currents show variable activation kinetics and Ca2+?dependence.Icilin-evoked currents exhibit highly variable latencies with pronounced desensitization. Cell Viability Assay Cell Line:TRPM8-expressing oocytes or HEK293 cells Concentration:10 μM Incubation Time:3 minutes for TRPM8-expressing oocytes; 1 minute for HEK293 cells Result:Activated membrane currents with variable delay of onset in voltage-clamped TRPM8-expressing oocytes or HEK293 cells.

Icilin is a transient receptor potential cation channel subfamily M (TRPM8) agonist that produces behavioral activation in rats and mice. Icilin?(3 mg/kg; s.c.) induces“Wet dog shake” in mice. Animal Model:The C57BL/6 mice 9–10 weeks (adult, 26-30 g) or 24 months (aged, 35-42g).Dosage:3 mg/kg Administration:Injected s.c.Result:Produced vivid and quantifiable shaking behaviors (“wet-dog shakes”), which were TRPM8-dependent.?

AG 3-5

Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRPM8

Cancer

——

36945-98-9

311.29

C16H13N3O4

>98% (HPLC)

DMSO: 10 mM

O=C1NC(C2=CC=CC([N+]([O-])=O)=C2)=CCN1C3=CC=CC=C3O

3,6-Dihydro-1-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2(1H)-pyrimidinone

(-20℃)

With Ice Pack

≥ 2 years