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Raphin1
CAS No. 2022961-17-5
Raphin1 ( —— )
产品货号. M21085 CAS No. 2022961-17-5
Raphin1 是一种口服生物可利用的调节性磷酸酶 PPP1R15B (R15B) 的选择性抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥253 | 有现货 |
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| 10MG | ￥392 | 有现货 |
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| 25MG | ￥697 | 有现货 |
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| 50MG | ￥1042 | 有现货 |
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| 100MG | ￥1485 | 有现货 |
|
| 200MG | ￥2115 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥235 | 有现货 |
|
生物学信息
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产品名称Raphin1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Raphin1 是一种口服生物可利用的调节性磷酸酶 PPP1R15B (R15B) 的选择性抑制剂。
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产品描述Raphin1 is an orally bioavailable selective inhibitor of the regulatory phosphatase PPP1R15B (R15B).
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体外实验Raphin1 causes a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis.Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.
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体内实验Raphin1 improves weight of HD82Q mice treated from 4 to ～10 weeks of age with 2 mg/kg of Raphin1 once a day by oral gavage. Raphin1 also decreases SDS-insoluble huntingtin assemblies and nuclear inclusions in the cortex of HD82Q mice.
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同义词——
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通路Metabolic Enzyme/Protease
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靶点Phosphatase
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受体Phosphatase
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研究领域——
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适应症——
化学信息
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CAS Number2022961-17-5
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分子量231.08
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分子式C8H8Cl2N4
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纯度>98% (HPLC)
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溶解度DMSO:125 mg/mL?(540.94 mM ;?
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SMILESN=C(N)N/N=C/c1cccc(Cl)c1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Krzyzosiak A Sigurdardottir A Luh Let al.Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.Cell. 2018 Aug 23 ;174(5):1216-1228.e19.?
产品手册
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