Datelliptium chloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Datelliptium氯化物是一种从玫瑰树碱中提取的DNA嵌入剂。具有抗肿瘤活性。

Datelliptium chloride is a DNA-intercalating agent derived from ellipticine. with anti-tumor activities.

Datelliptium (100 μM) shows significantly cytotoxic effects after 2 hr of treatment in suspension and primary cultures of rat hepatocytes. Datelliptium mobilizes glycogen in both rat systems in vitro concentration dependently. The half-maximal effect is 14.3 μM in isolated hepatocytes, whereas in cultured rat hepatocytes it is 5.9 μM. Datelliptium also leads to a concentration-dependent decrease in gluconeogenesis from lactate in cells. Datelliptium acetate is selectively cytotoxic for solid tumors over leukemia L1210. Human tumors H-125 and HCT-116 demonstrates less sensitivity to datelliptium acetate.

Upon intravenous administration, datelliptium acetate shows potent inhibitory activities in vivo against a variety of murine solid tumors. Datelliptium acetate is highly active against early-stage colon #38 with highest non-toxic dose (HNTD) of 170 mg/kg TD, and weight loss of 10%, T/C of 0%.

——

Cell Cycle/DNA Damage

DNA/RNA Synthesis

DNA synthesis

——

——

105118-14-7

397.94

C23H28ClN3O

>98% (HPLC)

H2O:41.67 mg/mL (104.71 mM; Need ultrasonic)

CCN(CC)CC[n+]1ccc2c(C)c3[nH]c4ccc(O)cc4c3c(C)c2c1.[Cl-]

——

(-20℃)

With Ice Pack

≥ 2 years