Nanaomycin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Nanaomycin A 是一种醌类抗生素，可重新激活人类癌细胞中沉默的肿瘤抑制基因。 Nanaomycin A 是 DNMT3B 的选择性抑制剂 (IC50 = 500 nM)。

Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM). (In Vitro):Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM. Nanaomycin A (10, 100, 1000, 10000 nM) had a distinct cytotoxic effect in HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines. Nanaomycin A (5 μM) had an 18-fold relative induction. Nanaomycin A (0.5, 5 μM) revealed induction of RASSF1A protein expression in A549 cells.

Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines.Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells. Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction. Nanaomycin A not affects the enzymatic activity of DNMT1. Cell Cytotoxicity Assay Cell Line:HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines Concentration:10, 100, 1000, 10000 nM Incubation Time:72 hours Result:Had a distinct cytotoxic effect in all three cell lines.Western Blot Analysis Cell Line:A549 cells Concentration:0.5, 5 μM Incubation Time:72 hours Result:Revealed induction of RASSF1A protein expression.RT-PCR Cell Line:A549 cells Concentration:5 μM Incubation Time:72 hours Result:Had an 18-fold relative induction.

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

Apoptosis| Nucleoside Antimetabolite/Analog

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52934-83-5

302.282

C16H14O6

>98% (HPLC)

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C[C@@H]1O[C@@H](CC(O)=O)CC2=C1C(=O)c1c(O)cccc1C2=O

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(-20℃)

With Ice Pack

≥ 2 years