BMS-191011

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

BMS-191011 是一种大电导钙激活钾 (BKCa) 通道激活剂，对中风模型有效。

BMS-191011 is an activator of large-conductance calcium-activated potassium (BKCa) channels effective in stroke models.

BMS-191011 (20 or 40 μM) activates BK channels in IGR39 cells, and leads to potentiation in Panc-1 cells. Cell Viability Assay Cell Line:IGR39 and Panc-1 cells Concentration:20 or 40 μM Incubation Time:Result:Activated BK channels in less than 50% IGR39 cells and led to less than two-fold potentiation in Panc-1 cells.Promoted the activation of a voltage-independent K+ conductance at negative voltages.

BMS-191011 (intravenous injection; 10-100 μg/kg; once) dilates rat retinal arterioles through activation of iberiotoxin-sensitive BK(Ca) channels in vivo. Animal Model:Male Wistar rats (8- to 10-week-old) treated with Tetrodotoxin (50 μg/kg, intravenously (i.v.)) Dosage:10-100 μg/kg Administration:Intravenous injection; 10-100 μg/kg; once Result:Increased the diameter of retinal arterioles, showed no significant effect on mean arterial pressure and heart rate.

BMS-A

Cell Cycle/DNA Damage

Potassium Channel

Potassium Channel

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202821-81-6

370.71

C16H10ClF3N2O3

>98% (HPLC)

DMSO:125 mg/mL (337.19 mM)

O=c1oc(-c2ccc(C(F)(F)F)cc2)nn1Cc1cc(Cl)ccc1O

134-Oxadiazol-2(3H)-one 3-((5-chloro-2-hydroxyphenyl)methyl)-5-(4-(trifluoromethyl)phenyl)-

(-20℃)

With Ice Pack

≥ 2 years