MTEP hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MTEP 盐酸盐是非竞争性 mGlu5 拮抗剂（IC50 和 Ki 分别为 5 nM 和 16 nM）。

MTEP hydrochloride is non-competitive mGlu5 antagonist (IC50 and Ki of 5 nM and 16 nM respectively).(In Vitro):MTEP shows highly selective for mGluR5 over mGluR1, has no effect on other mGluR subtypes, and has fewer off-target effects than MPEP (HY-14609A).(In Vivo):MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.).MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice.

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Animal Model:Male Wistar rats (215-315 g, 5-9/group)Dosage:1, 3 and 5 mg/kg Administration:IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)Result:Inhibited the catalepsy induced by Haloperidol (HY-14538).Animal Model:Male C57BL/6J mice (23-25 g)Dosage:0.3, 1 and 3 mg/kg Administration:IP, 1 h before the testResult:Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard.

3-((2-Methyl-13-thiazol-4-yl)ethyn-yl)pyridine hydrochloride | MTEP

Neuroscience

GluR

mGluR

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1186195-60-7

236.72

C11H9ClN2S

>98% (HPLC)

H2O:20 mg/mL (84.49 mM; Need ultrasonic)

Cc1nc(C#Cc2cccnc2)cs1.Cl

3-((2-Methyl-13-thiazol-4-yl)ethynyl)pyridine hydrochloride

(-20℃)

With Ice Pack

≥ 2 years