RN-1734

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RN-1734是选择性TRPV4通道拮抗剂（hTRPV4、mTRPV4和rTRPV4的IC50分别为2.3 μM、5.9 μM、3.2 μM）。

RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 μM5.9 μM3.2 μM for hTRPV4 ?mTRPV4 and rTRPV4respectively).

Apoptosis Analysis Cell Line: Microglial cells Concentration:27 hours Incubation Time:10μM Result:Significantly decreased the percentage of cleaved-caspase 3 positive cells.Western Blot Analysis Cell Line:Microglial cells Concentration:27 hours Incubation Time:10 μM esult:Alleviated CM (with LPS only)-induced decreases in CNP.

Animal Model:CPZ-induced demyelination mouse model (C57BL/6 male mice)Dosage: 0.5 μl (10 μM in 5% DMSO and 0.9% NaCl)Administration:Microinjector pump for 5 weeks Result:Significantly reversed the decrease in CNP protein and improved myelination in CPZ-induced demyelination mouse.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

hTRPV4

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946387-07-1

353.31

C14H22Cl2N2O2S

>98% (HPLC)

DMSO:50 mg/mL (141.52 mM)

CC(C)NCCN(C(C)C)S(=O)(=O)c1ccc(Cl)cc1Cl

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(-20℃)

With Ice Pack

≥ 2 years