TRPV3 antagonist 74a

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TRPV3 antagonist 74a 是一种有效的选择性 TRPV3 拮抗剂。TRPV3 antagonist 74a 对其他离子通道面板显示无显著活性。TRPV3 antagonist 74a 可用于神经性疼痛的研究。

TRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain.

TRPV3 antagonist 74a (100 μΜ; 2300 seconds; keratinocytes) largely attenuates SLIGRL or SLIGKV-induced Ca2+ responses.

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly..TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold.Animal Model:WT mice Dosage:150 μg Administration:Intradermal injection; 30 minutes Result:The number of scratches decreased significantly.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRP/TRPV Channel

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1432051-63-2

338.32

C17H17F3N2O2

>98% (HPLC)

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[C@H](O)([C@]1(C[C@@](C)(O)C1)C2=CC(C(F)(F)F)=CC=N2)C3=CC=CC=N3

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(-20℃)

With Ice Pack

≥ 2 years