021-51111890
购物车（）
sales@molnova.cn
DHBP dibromide
CAS No. 6159-05-3
DHBP dibromide ( Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO )
产品货号. M20752 CAS No. 6159-05-3
DHBP 二溴化物是钙释放剂和肌肉松弛抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 50MG | ￥100 | 有现货 |
|
| 100MG | ￥129 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称DHBP dibromide
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述DHBP 二溴化物是钙释放剂和肌肉松弛抑制剂。
-
产品描述DHBP dibromide is calcium release and a muscle relaxant inhibitor.
-
体外实验DHBP inhibits the calcium release induced by 2 mM caffeine and 2 μg/mL polylysine with an IC50 value of 5 μg/mL and 4 μg/mL, respectively. DHBP inhibits [3H]-ryanodine binding in a dose-dependent manner with an IC50 of 2.5 μg/mL and 90-100% inhibition at 20-30 μg/mL. Calcium uptake by SR is inhibited in the presence of caffeine and this inhibition is antagonized by concomitant addition of DHBP. Muscle twitches elicited by direct electrical muscle stimulation and contractions induced by either 10 mM caffeine or 1 fLM ryanodine are blocked by pretreatment with DHBP. DHBP blocks the calcium release from SR by direct interaction with the calcium release channel, also known as the ryanodine receptor.
-
体内实验——
-
同义词Diheptylviologen dibromide | 11'-DI-N-HEPTYL-44'-BIPYRIDINIUM DIBRO
-
通路GPCR/G Protein
-
靶点Calcium Channel
-
受体Calcium Channel
-
研究领域——
-
适应症——
化学信息
-
CAS Number6159-05-3
-
分子量514.38
-
分子式C24H38Br2N2
-
纯度>98% (HPLC)
-
溶解度DMSO:30 mg/mL (58.32 mM)
-
SMILES[Br-].[Br-].CCCCCCC[n+]1ccc(cc1)-c1cc[n+](CCCCCCC)cc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Aguilar-Sanchez Y Difranco M Darcy Y L et al. DHBP Reversibly Inhibits Calcium Release from Sarcoplasmic Reticulum (SR) in Skeletal Muscle and Heart[J]. Biophysical Journal 2017 112(3):161a-162a.
产品手册
关联产品
-
(S)-(-)-Bay-K-8644
(S)-(-)-Bay-K-8644 是 L 型 Ca2+ 通道的激动剂，可激活 Ba2+ 电流，EC50 为 32 nM。
-
CRAC intermediate 1
CRAC中间体1是一系列CRAC通道抑制剂化学合成的关键中间体。
-
Barnidipine(b)
巴尼地平是一种钙通道阻滞剂。
