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Ombitasvir
CAS No. 1258226-87-7
Ombitasvir ( ABT-267 )
产品货号. M20637 CAS No. 1258226-87-7
Ombitasvir 是一种口服生物利用度强的丙型肝炎病毒 (HCV) 非结构蛋白 5A (NS5A) 抑制剂。针对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM，针对基因型 6a 的 EC50 为 366 pM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥708 | 有现货 |
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| 10MG | ￥1102 | 有现货 |
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| 25MG | ￥2213 | 有现货 |
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| 50MG | ￥3236 | 有现货 |
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| 100MG | ￥4464 | 有现货 |
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| 200MG | ￥6174 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1074 | 有现货 |
|
生物学信息
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产品名称Ombitasvir
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ombitasvir 是一种口服生物利用度强的丙型肝炎病毒 (HCV) 非结构蛋白 5A (NS5A) 抑制剂。针对 HCV 基因型 1 至 5 的 EC50 为 0.82 至 19.3 pM，针对基因型 6a 的 EC50 为 366 pM。
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产品描述Ombitasvir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5 and 366 pM against genotype 6a.(In Vitro):Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.
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体外实验Ombitasvir is active against the genotype 2a JFH-1 replicon, with an EC50 of 0.82 pM, and the EC50s of ombitasvir are 42 pM and 68 pM against the L28 and F28 variants of this genotype 6a replicon, respectively. In GT1a, variants M28V, L31V, and H58D confers 58- to 243-fold resistance to Ombitasvir. Single variants M28T, Q30R, and Y93C/S confers 800- to 8965-fold resistance, while Y93H/N confers >40000-fold resistance to Ombitasvir.
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体内实验——
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同义词ABT-267
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通路Microbiology/Virology
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靶点HCV
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受体HCV NS5A
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研究领域Inflammation/Immunology
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适应症hepatitis C virus (HCV) infection
化学信息
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CAS Number1258226-87-7
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分子量894.11
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分子式C50H67N7O8
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纯度>98% (HPLC)
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溶解度DMSO:33 mg/mL (36.91 mM)
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SMILESCOC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)Nc1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc(NC(=O)[C@@H]2CCCN2C(=O)[C@@H](NC(=O)OC)C(C)C)cc1
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化学全称L-Prolinamide22'-(((2S5S)-1-(4-(11-dimethylethyl)phenyl)-25-pyrrolidinediyl)di-41-phenylene)bis(N-(methoxycarbonyl)-L-valyl-
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Krishnan P Beyer J Mistry Net al.in vitro and in vivo antiviral activity and resistance profile of ombitasvir an inhibitor of hepatitis c virus ns5a[J].Antimicrob Agents Chemother. 2015 Feb;59(2):979-87.
