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Phenylbiguanide
CAS No. 102-02-3
Phenylbiguanide ( N-Phenylbiguanide | PBG | 1-Phenylbiguanide )
产品货号. M20627 CAS No. 102-02-3
Phenylbiguanide 是一种 5-HT3 受体选择性激动剂（EC50 : 3.0±0.1 μM）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥138 | 有现货 |
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| 25MG | ￥216 | 有现货 |
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| 50MG | ￥312 | 有现货 |
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| 100MG | ￥444 | 有现货 |
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| 500MG | ￥1062 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥181 | 有现货 |
|
生物学信息
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产品名称Phenylbiguanide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Phenylbiguanide 是一种 5-HT3 受体选择性激动剂（EC50 : 3.0±0.1 μM）。
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产品描述Phenylbiguanide is a 5-HT3 receptor selective agonist(EC50 : 3.0±0.1 μM).
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体外实验Phenylbiguanide (1-Phenylbiguanide) is a 5-HT3 receptor selective agonist with pEC50s of 5.57, 4.07, and 4.47 for r5-HT3A(b), h5-HT3A, m5-HT3A(b) , respectively. The effect of Phenylbiguanide (1-Phenylbiguanide hydrochloride) in promoting the growth of the HT29 cell line is investigated. Phenylbiguanide causes a dose dependent proliferation of HT29 cells after 48 hours incubation. The maximum proliferation is at a 5HT concentration of 12.5 μM (P≤0.01). Phenylbiguanide significantly stimulates the growth of cells at concentrations of 3.125 μM (P≤0.05) and 6.25 μM (P≤0.01).
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体内实验In anaesthetised mice, Phenylbiguanide (PBG), a drug that is known to stimulate cardiopulmonary afferent C-fibres,is injected into the right atrium of the heart and mapped c-Fos expression within specific regions of the central nervous system. Intraatrial injection of PBG produces a reflex cardiorespiratory response including a pronounced bradycardia and a respiratory depression.
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同义词N-Phenylbiguanide | PBG | 1-Phenylbiguanide
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT3
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研究领域——
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适应症——
化学信息
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CAS Number102-02-3
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分子量177.21
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分子式C8H11N5
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纯度>98% (HPLC)
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溶解度DMSO:150 mg/mL (846.45 mM)
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SMILESNC(=N)NC(=N)Nc1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.de Vries A Paton JF Lightman SLet al.Characterisation of c-Fos expression in the central nervous system of mice following right atrial injections of the 5-HT3 receptor agonist phenylbiguanide[J].Auton Neurosci. 2005 Dec 30;123(1-2):62-75.
